Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data

Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data

There are no robust methods for systematically identifying mutation-specific synthetic lethal (SL) partners in cancer. Here, the authors develop a computational algorithm that uses pan-cancer data to detect mutation-andcancer-specific SL partners and they validate a novel SL interaction between muta...

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Bibliographic Details
Main Authors: Subarna Sinha, Daniel Thomas, Steven Chan, Yang Gao, Diede Brunen, Damoun Torabi, Andreas Reinisch, David Hernandez, Andy Chan, Erinn B. Rankin, Rene Bernards, Ravindra Majeti, David L. Dill
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15580

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https://doi.org/10.1038/ncomms15580

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