Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies

The analysis of genome-wide association studies (GWAS) benefits from the investigation of biologically meaningful gene sets, such as gene-interaction networks (pathways). We propose an extension to a successful kernel-based pathway analysis approach by integrating kernel functions into a powerful al...

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Bibliographic Details
Main Authors: Stefanie Friedrichs, Juliane Manitz, Patricia Burger, Christopher I. Amos, Angela Risch, Jenny Chang-Claude, Heinz-Erich Wichmann, Thomas Kneib, Heike Bickeböller, Benjamin Hofner
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Computational and Mathematical Methods in Medicine
Online Access:http://dx.doi.org/10.1155/2017/6742763