Fetal Brain-directed AAV Gene Therapy Results in Rapid, Robust, and Persistent Transduction of Mouse Choroid Plexus Epithelia

Fetal Brain-directed AAV Gene Therapy Results in Rapid, Robust, and Persistent Transduction of Mouse Choroid Plexus Epithelia

Fetal brain-directed gene addition represents an under-appreciated tool for investigating novel therapeutic approaches in animal models of central nervous system diseases with early prenatal onset. Choroid plexuses (CPs) are specialized neuroectoderm-derived structures that project into the brain�...

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Bibliographic Details
Main Authors: Marie Reine Haddad, Anthony Donsante, Patricia Zerfas, Stephen G Kaler
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
blood-cerebrospinal fluid barrier
choroid plexus
in utero gene therapy
rAAV5
rAAV9
survival surgery
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301597

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http://www.sciencedirect.com/science/article/pii/S2162253116301597

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