Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function.

Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function.

The bone morphogenetic protein (BMP) type II receptor (BMPR2) has a long cytoplasmic tail domain whose function is incompletely elucidated. Mutations in the tail domain of BMPR2 are found in familial cases of pulmonary arterial hypertension. To investigate the role of the tail domain of BMPR2 in BMP...

Full description

Bibliographic Details
Main Authors: Patricio A Leyton, Hideyuki Beppu, Alexandra Pappas, Trejeeve M Martyn, Matthias Derwall, David M Baron, Rita Galdos, Donald B Bloch, Kenneth D Bloch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3792867?pdf=render

Internet

http://europepmc.org/articles/PMC3792867?pdf=render

Similar Items