Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity

Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity

Background: Mutations in glucocerebrosidase (GBA), a lysosomal enzyme are the most common genetic risk factor for developing Parkinson's disease (PD). We studied how reduced GCase activity affects α-synuclein (α-syn) and its mutants (A30P and A53T) aggregation, neurodegeneration, sleep and loco...

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Bibliographic Details
Main Authors: Salema B. Abul Khair, Nisha R. Dhanushkodi, Mustafa T. Ardah, Wenfeng Chen, Yufeng Yang, M. Emdadul Haque
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson's disease
GBA
Drosophila
synuclein
neurodegeneration
sleep behavior
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00081/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00081/full

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