Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.

Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.

Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of coronary artery disease (CAD) and the causal mechanisms at the majority of loci are unknown. Recent studies have suggested that many causal GWAS variants influence disease through altered transcriptional regulati...

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Bibliographic Details
Main Authors: Michael E Reschen, Kyle J Gaulton, Da Lin, Elizabeth J Soilleux, Andrew J Morris, Susan S Smyth, Christopher A O'Callaghan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4383549?pdf=render

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http://europepmc.org/articles/PMC4383549?pdf=render

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