Are tau aggregates toxic or protective in tauopathies?
Aggregation of highly-phosphorylated tau into aggregated forms such as filaments and neurofibrillary tangles is one of the defining pathological hallmarks of Alzheimer’s disease and other tauopathies. Hence therapeutic strategies have focused on inhibition of tau phosphorylation or disruption of agg...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-08-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00114/full |