Quality by Design Based Optimization of a High Performance Liquid Chromatography Method for Assay Determination of Low Concentration Preservatives in Complex Nasal Formulations

The effects of seven different chromatographic parameters and five sample preparation parameters in a high performance liquid chromatography (HPLC) method for assay determination of benzalkonium chloride (BKC) in a nasal formulation were evaluated using two fractional factorial experimental designs....

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Bibliographic Details
Main Authors: Jure Zakrajšek, Vladimir Stojić, Simona Bohanec, Uroš Urleb
Format: Article
Language:English
Published: Slovenian Chemical Society 2015-03-01
Series:Acta Chimica Slovenica
Subjects:
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/718