Low dose rapamycin exacerbates autoimmune experimental uveitis.

Rapamycin, a potent immune modulator, is used to treat transplant rejection and some autoimmune diseases. Uveitis is a potentially severe inflammatory eye disease, and 2 clinical trials of treating uveitis with rapamycin are under way. Unexpectedly, recent research has demonstrated that low dose rap...

Full description

Bibliographic Details
Main Authors: Zili Zhang, Xiumei Wu, Jie Duan, David Hinrichs, Keith Wegmann, Gary L Zhang, Mark Hall, James T Rosenbaum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3344911?pdf=render