Extracellular tyrosyl‐tRNA synthetase cleaved by plasma proteinases and stored in platelet α‐granules: Potential role in monocyte activation

Extracellular tyrosyl‐tRNA synthetase cleaved by plasma proteinases and stored in platelet α‐granules: Potential role in monocyte activation

Abstract Background Tyrosyl‐tRNA synthetase (YRS) belongs to the family of enzymes that catalyzes the tRNA aminoacylation reaction for protein synthesis, and it has been recently shown to exert noncanonical functions. Although database results indicate extremely low levels of YRS mRNA in platelets,...

Full description

Bibliographic Details
Main Authors: Eric Won, Yosuke Morodomi, Sachiko Kanaji, Ryan Shapiro, My‐Nuong Vo, Jennifer N. Orje, Courtney D. Thornburg, Xiang‐Lei Yang, Zaverio M. Ruggeri, Paul Schimmel, Taisuke Kanaji
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
elastase
matrix metalloproteinases (MMPs)
monocytes
platelets
tyrosyl‐tRNA synthetase (YRS)
α‐granules
Online Access:https://doi.org/10.1002/rth2.12429

Internet

https://doi.org/10.1002/rth2.12429

Similar Items