Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice

Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice

Pancreatic disorders: when protein modification misfires Reduced levels of a protein called Cosmc in the pancreas may lead to pancreatic disorders and a rare form of diabetes. Disruption to glycosylation, the process by which carbohydrates are added to proteins, can have significant knock-on effects...

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Bibliographic Details
Main Authors: Gerrit Wolters-Eisfeld, Baris Mercanoglu, Bianca T. Hofmann, Thomas Wolpers, Claudia Schnabel, Sönke Harder, Pascal Steffen, Kai Bachmann, Babett Steglich, Jörg Schrader, Nicola Gagliani, Hartmut Schlüter, Cenap Güngör, Jakob R. Izbicki, Christoph Wagener, Maximilian Bockhorn
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-018-0157-3

Internet

https://doi.org/10.1038/s12276-018-0157-3

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