Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates.

Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates.

Non-alcoholic fatty liver disease (NAFLD) is characterized by accumulation of triglycerides (TG) in hepatocytes, which may also trigger cirrhosis. The mechanisms of NAFLD are not fully understood, but insulin resistance has been proposed as a key determinant.To determine the TG content and long chai...

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Main Authors: Subhash Kamath, Alberto O Chavez, Amalia Gastaldelli, Francesca Casiraghi, Glenn A Halff, Gregory A Abrahamian, Alberto M Davalli, Raul A Bastarrachea, Anthony G Comuzzie, Rodolfo Guardado-Mendoza, Lilia M Jimenez-Ceja, Vicki Mattern, Ana Maria Paez, Andrea Ricotti, Mary E Tejero, Paul B Higgins, Iram Pablo Rodriguez-Sanchez, Devjit Tripathy, Ralph A DeFronzo, Edward J Dick, Gary W Cline, Franco Folli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3220682?pdf=render

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http://europepmc.org/articles/PMC3220682?pdf=render

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