Functional roles of protein splicing factors
RNA splicing is one of the fundamental processes in gene expression in eukaryotes. Splicing of pre-mRNA is catalysed by a large ribonucleoprotein complex called the spliceosome, which consists of five small nuclear RNAs and numerous protein factors. The spliceosome is a highly dynamic structure, ass...
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doaj-e4d7511b6c5f46cc887f1a735ed191472020-11-24T22:00:05ZengPortland Press, Biochemical SocietyBioscience Reports0144-84631573-49352012-04-0132410.1042/BSR20120007Functional roles of protein splicing factorsHsin‑Chou ChenSoo‑Chen ChengRNA splicing is one of the fundamental processes in gene expression in eukaryotes. Splicing of pre-mRNA is catalysed by a large ribonucleoprotein complex called the spliceosome, which consists of five small nuclear RNAs and numerous protein factors. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors. DExD/H-box RNA helicases are required to mediate structural changes in the spliceosome at various steps in the assembly pathway and have also been implicated in the fidelity control of the splicing reaction. Other proteins also play key roles in mediating the progression of the spliceosome pathway. In this review, we discuss the functional roles of the protein factors involved in the spliceosome pathway primarily from studies in the yeast system.http://www.bioscirep.org/bsr/032/0345/bsr0320345.htmprotein splicing factorRNA splicingsmall nuclear ribonucleoprotein (snRNP)spliceosomeyeast |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hsin‑Chou Chen Soo‑Chen Cheng |
spellingShingle |
Hsin‑Chou Chen Soo‑Chen Cheng Functional roles of protein splicing factors Bioscience Reports protein splicing factor RNA splicing small nuclear ribonucleoprotein (snRNP) spliceosome yeast |
author_facet |
Hsin‑Chou Chen Soo‑Chen Cheng |
author_sort |
Hsin‑Chou Chen |
title |
Functional roles of protein splicing factors |
title_short |
Functional roles of protein splicing factors |
title_full |
Functional roles of protein splicing factors |
title_fullStr |
Functional roles of protein splicing factors |
title_full_unstemmed |
Functional roles of protein splicing factors |
title_sort |
functional roles of protein splicing factors |
publisher |
Portland Press, Biochemical Society |
series |
Bioscience Reports |
issn |
0144-8463 1573-4935 |
publishDate |
2012-04-01 |
description |
RNA splicing is one of the fundamental processes in gene expression in eukaryotes. Splicing of pre-mRNA is catalysed by a large ribonucleoprotein complex called the spliceosome, which consists of five small nuclear RNAs and numerous protein factors. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors. DExD/H-box RNA helicases are required to mediate structural changes in the spliceosome at various steps in the assembly pathway and have also been implicated in the fidelity control of the splicing reaction. Other proteins also play key roles in mediating the progression of the spliceosome pathway. In this review, we discuss the functional roles of the protein factors involved in the spliceosome pathway primarily from studies in the yeast system. |
topic |
protein splicing factor RNA splicing small nuclear ribonucleoprotein (snRNP) spliceosome yeast |
url |
http://www.bioscirep.org/bsr/032/0345/bsr0320345.htm |
work_keys_str_mv |
AT hsinx2011chouchen functionalrolesofproteinsplicingfactors AT soox2011chencheng functionalrolesofproteinsplicingfactors |
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