Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats

Abstract Background Targeting endogenous blood–brain barrier (BBB) transporters such as organic anion transporting polypeptide 1a4 (Oatp1a4) can facilitate drug delivery for treatment of neurological diseases. Advancement of Oatp targeting for optimization of CNS drug delivery requires characterizat...

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Bibliographic Details
Main Authors: Hrvoje Brzica, Wazir Abdullahi, Bianca G. Reilly, Patrick T. Ronaldson
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Fluids and Barriers of the CNS
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12987-018-0110-9