Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics

Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics

The current treatment regimen for lymphatic filariasis is mostly microfilaricidal. In an effort to identify new drug candidates for lymphatic filariasis, we conducted a three-way transcriptomics/systems biology study of one of the causative agents of lymphatic filariasis, Brugia malayi, its Wolbachi...

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Bibliographic Details
Main Authors: Matthew Chung, Laura E. Teigen, Silvia Libro, Robin E. Bromley, Dustin Olley, Nikhil Kumar, Lisa Sadzewicz, Luke J. Tallon, Anup Mahurkar, Jeremy M. Foster, Michelle L. Michalski, Julie C. Dunning Hotopp
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSystems
Subjects:
lymphatic filariasis
filarial nematodes
nematodes
brugia malayi
wolbachia
aedes aegypti
mosquito
transcriptomics
rna-seq
multispecies rna-seq
bromodomain
bromodomain inhibitor
6s rna
brugia
drug repurposing
neglected tropical disease
symbiosis
Online Access:https://doi.org/10.1128/mSystems.00596-19

Internet

https://doi.org/10.1128/mSystems.00596-19

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