Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

TRPV1 channels support the detection of noxious and nociceptive input. Currently available functional and structural data suggest that TRPV1 channels have two gates within their permeation pathway: one formed by a ′bundle-crossing′ at the intracellular entrance and a second constriction at the selec...

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Bibliographic Details
Main Authors: Ximena Steinberg, Marina A Kasimova, Deny Cabezas-Bratesco, Jason D Galpin, Ernesto Ladron-de-Guevara, Federica Villa, Vincenzo Carnevale, Leon Islas, Christopher A Ahern, Sebastian E Brauchi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
TRPV1
gating
non-canonical amino acids
coumarin
pore
SPAD
Online Access:https://elifesciences.org/articles/28626

Internet

https://elifesciences.org/articles/28626

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