Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trial
Establishing health effects of bioactive compounds from dry-cured meat is an active area of clinical research. The present study aims to investigate whether consuming dry-cured ham with biopeptides, among other bioactive compounds, modifies blood pressure (BP) and improves other risk factors for car...
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doaj-e4e50bafbe2448bdaf53999a9acc75fa2021-04-30T07:11:41ZengElsevierJournal of Functional Foods1756-46462017-11-0138160167Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trialSilvia Montoro-García0María Pilar Zafrilla-Rentero1Francisco Miguel Celdrán-de Haro2Juan José Piñero-de Armas3Fidel Toldrá4Luis Tejada-Portero5José Abellán-Alemán6Cátedra de Riesgo Cardiovascular y Departamento de Nutrición, Facultad de Ciencias de la Salud, UCAM Universidad Católica San Antonio de Murcia, Campus de los Jerónimos, s/n, Guadalupe 30107, Murcia, Spain; Corresponding author at: Cátedra de Riesgo Cardiovascular, Facultad de Ciencias de la Salud, UCAM Universidad Católica San Antonio de Murcia, Campus de los Jerónimos, s/n, Guadalupe 30107, Murcia, Spain.Cátedra de Riesgo Cardiovascular y Departamento de Nutrición, Facultad de Ciencias de la Salud, UCAM Universidad Católica San Antonio de Murcia, Campus de los Jerónimos, s/n, Guadalupe 30107, Murcia, SpainCátedra de Riesgo Cardiovascular y Departamento de Nutrición, Facultad de Ciencias de la Salud, UCAM Universidad Católica San Antonio de Murcia, Campus de los Jerónimos, s/n, Guadalupe 30107, Murcia, SpainCátedra de Estadística “Big data”, UCAM Universidad Católica San Antonio de Murcia, SpainInstituto de Agroquímica y Tecnología de Alimentos, CSIC, Av Agustín Escardino 7, 46980 Paterna, Valencia, SpainCátedra de Riesgo Cardiovascular y Departamento de Nutrición, Facultad de Ciencias de la Salud, UCAM Universidad Católica San Antonio de Murcia, Campus de los Jerónimos, s/n, Guadalupe 30107, Murcia, SpainCátedra de Riesgo Cardiovascular y Departamento de Nutrición, Facultad de Ciencias de la Salud, UCAM Universidad Católica San Antonio de Murcia, Campus de los Jerónimos, s/n, Guadalupe 30107, Murcia, SpainEstablishing health effects of bioactive compounds from dry-cured meat is an active area of clinical research. The present study aims to investigate whether consuming dry-cured ham with biopeptides, among other bioactive compounds, modifies blood pressure (BP) and improves other risk factors for cardiovascular disease in humans. This two-arm, cross-over, randomised controlled trial involved 38 healthy subjects with pre-hypertension. Participants received 80 g/day dry-cured pork ham or 100 g/day cooked ham (control product). A daily intake of 80 g dry-cured ham did not impair BP or 24 h sodium excretion. Total cholesterol, LDL and basal glucose levels dropped after dry-cured ham consumption (p = 0.00019, p = 0.021 and p = 0.014, respectively). Cooked ham did not affect any of the clinical and biochemical markers. Dry-cured ham components could exert a plethora of activities over the cardiovascular system including lipid and glucose metabolism. Additional studies are needed to confirm the effects of dry-cured meat biopeptides on diverse risk factors in pathological conditions.http://www.sciencedirect.com/science/article/pii/S1756464617305248Dry-cured hamBioactive peptidesHypertensionACE inhibitionCardiovascular risk factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Silvia Montoro-García María Pilar Zafrilla-Rentero Francisco Miguel Celdrán-de Haro Juan José Piñero-de Armas Fidel Toldrá Luis Tejada-Portero José Abellán-Alemán |
spellingShingle |
Silvia Montoro-García María Pilar Zafrilla-Rentero Francisco Miguel Celdrán-de Haro Juan José Piñero-de Armas Fidel Toldrá Luis Tejada-Portero José Abellán-Alemán Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trial Journal of Functional Foods Dry-cured ham Bioactive peptides Hypertension ACE inhibition Cardiovascular risk factors |
author_facet |
Silvia Montoro-García María Pilar Zafrilla-Rentero Francisco Miguel Celdrán-de Haro Juan José Piñero-de Armas Fidel Toldrá Luis Tejada-Portero José Abellán-Alemán |
author_sort |
Silvia Montoro-García |
title |
Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trial |
title_short |
Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trial |
title_full |
Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trial |
title_fullStr |
Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trial |
title_full_unstemmed |
Effects of dry-cured ham rich in bioactive peptides on cardiovascular health: A randomized controlled trial |
title_sort |
effects of dry-cured ham rich in bioactive peptides on cardiovascular health: a randomized controlled trial |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2017-11-01 |
description |
Establishing health effects of bioactive compounds from dry-cured meat is an active area of clinical research. The present study aims to investigate whether consuming dry-cured ham with biopeptides, among other bioactive compounds, modifies blood pressure (BP) and improves other risk factors for cardiovascular disease in humans. This two-arm, cross-over, randomised controlled trial involved 38 healthy subjects with pre-hypertension. Participants received 80 g/day dry-cured pork ham or 100 g/day cooked ham (control product). A daily intake of 80 g dry-cured ham did not impair BP or 24 h sodium excretion. Total cholesterol, LDL and basal glucose levels dropped after dry-cured ham consumption (p = 0.00019, p = 0.021 and p = 0.014, respectively). Cooked ham did not affect any of the clinical and biochemical markers. Dry-cured ham components could exert a plethora of activities over the cardiovascular system including lipid and glucose metabolism. Additional studies are needed to confirm the effects of dry-cured meat biopeptides on diverse risk factors in pathological conditions. |
topic |
Dry-cured ham Bioactive peptides Hypertension ACE inhibition Cardiovascular risk factors |
url |
http://www.sciencedirect.com/science/article/pii/S1756464617305248 |
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