Spatial Heterogeneity in Large Resected Diffuse Large B-Cell Lymphoma Bulks Analysed by Massively Parallel Sequencing of Multiple Synchronous Biopsies

Spatial Heterogeneity in Large Resected Diffuse Large B-Cell Lymphoma Bulks Analysed by Massively Parallel Sequencing of Multiple Synchronous Biopsies

Diffuse large B-cell lymphoma (DLBCL) usually needs to be treated immediately after diagnosis from a single lymph node biopsy. However, several reports in other malignancies have shown substantial spatial heterogeneity within large tumours. Therefore, we collected multiple synchronous biopsies of tw...

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Bibliographic Details
Main Authors: Teresa Magnes, Sandro Wagner, Aaron R. Thorner, Daniel Neureiter, Eckhard Klieser, Gabriel Rinnerthaler, Lukas Weiss, Florian Huemer, Konstantin Schlick, Nadja Zaborsky, Markus Steiner, Richard Greil, Alexander Egle, Thomas Melchardt
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
diffuse large B-cell lymphoma
massively parallel sequencing
spatial heterogeneity
clonal evolution
lymphomagenesis
Online Access:https://www.mdpi.com/2072-6694/13/4/650

Internet

https://www.mdpi.com/2072-6694/13/4/650

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