Quantification of Inter-Sample Differences in T-Cell Receptor Repertoires Using Sequence-Based Information

Quantification of Inter-Sample Differences in T-Cell Receptor Repertoires Using Sequence-Based Information

Inter-sample comparisons of T-cell receptor (TCR) repertoires are crucial for gaining a better understanding of the immunological states determined by different collections of T cells from different donor sites, cell types, and genetic and pathological backgrounds. For quantitative comparison, most...

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Bibliographic Details
Main Authors: Ryo Yokota, Yuki Kaminaga, Tetsuya J. Kobayashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
T cell
TCR repertoire
inter-repertoire comparison
pairwise sequence alignment
sequence dissimilarity
manifold learning
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01500/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01500/full

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