NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly.

NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly.

Biogenesis of mammalian mitochondrial ribosomes requires a concerted maturation of both the small (SSU) and large subunit (LSU). We demonstrate here that the m(5)C methyltransferase NSUN4, which forms a complex with MTERF4, is essential in mitochondrial ribosomal biogenesis as mitochondrial translat...

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Bibliographic Details
Main Authors: Metodi Dimitrov Metodiev, Henrik Spåhr, Paola Loguercio Polosa, Caroline Meharg, Christian Becker, Janine Altmueller, Bianca Habermann, Nils-Göran Larsson, Benedetta Ruzzenente
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3916286?pdf=render

Internet

http://europepmc.org/articles/PMC3916286?pdf=render

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