Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality

Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality

Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamma (Fcγ) receptor-expressing immune cells. We previ...

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Bibliographic Details
Main Authors: Susan H. Tam, Stephen G. McCarthy, Anthony A. Armstrong, Sandeep Somani, Sheng-Jiun Wu, Xuesong Liu, Alexis Gervais, Robin Ernst, Dorina Saro, Rose Decker, Jinquan Luo, Gary L. Gilliland, Mark L. Chiu, Bernard J. Scallon
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Antibodies
Subjects:
Fc engineering
silent effector function
IgG1
IgG2
IgG4
IgG sigma
developability
pharmacokinetics
crystal structure
Online Access:https://www.mdpi.com/2073-4468/6/3/12

Internet

https://www.mdpi.com/2073-4468/6/3/12

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