HMGB1 Promotes the Release of Sonic Hedgehog From Astrocytes

HMGB1 Promotes the Release of Sonic Hedgehog From Astrocytes

High mobility group box 1 protein (HMGB1) is known to be a trigger of inflammation in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). However, it may play a different role in some way. Here we investigated the effect of HMGB1 on promoting sonic hedgehog (...

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Bibliographic Details
Main Authors: Yifan Xiao, Yan Sun, Wei Liu, FanFan Zeng, Junyu Shi, Jun Li, Huoying Chen, Chang Tu, Yong Xu, Zheng Tan, Feili Gong, Xiji Shu, Fang Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
sonic hedgehog (shh)
HMGB1
astrocytes
experimental autoimmune encephalomyelitis (EAE)
receptor for advanced glycation end products (RAGE)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.584097/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.584097/full

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