Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs for use in wild-type animals

Techniques to genetically manipulate the activity of defined neuronal subpopulations have been useful in elucidating function, however applicability to translational research beyond transgenic mice is limited. Subtype targeted transgene expression can be achieved using specific promoters, but often...

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Bibliographic Details
Main Authors: Heinrich S Gompf, Evgeny A Budygin, Patrick M Fuller, Caroline E Bass
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
aav
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00152/full