Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

Abstract Background Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM. Systemic delivery of chemotherapeutic drugs is hampered by the difficulty of achieving intratumoral levels as systemic...

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Bibliographic Details
Main Authors: Julio Enríquez Pérez, Jan Kopecky, Edward Visse, Anna Darabi, Peter Siesjö
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Cancer
Subjects:
Convection-enhanced delivery
Temozolomide
Whole cell vaccine immunotherapy
Mouse glioma
Online Access:https://doi.org/10.1186/s12885-019-6502-7

Internet

https://doi.org/10.1186/s12885-019-6502-7

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