Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β.

Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β.

<h4>Background</h4>NFκB signaling is critical for expression of genes involved in the vascular injury response. We have shown that estrogen (17β-estradiol, E2) inhibits expression of these genes in an estrogen receptor (ER)-dependent manner in injured rat carotid arteries and in tumor ne...

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Bibliographic Details
Main Authors: Dongqi Xing, Suzanne Oparil, Hao Yu, Kaizheng Gong, Wenguang Feng, Jonathan Black, Yiu-Fai Chen, Susan Nozell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22723832/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22723832/?tool=EBI

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