Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy

Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy

Background/Aims: Intervertebral disc degeneration (IDD) is a pathological process that is the primary cause of low back pain and is potentially mediated by compromised stress defense. Sestrins (Sesn) promote cell survival under stress conditions and regulate AMP-activated protein kinase (AMPK) and m...

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Bibliographic Details
Main Authors: Ji Tu, Wentian Li, Shuai Li, Wei Liu, Yukun Zhang, Xinghuo Wu, Rongjin Luo, Wenbin Hua, Kun Wang, Yu Song, Liang Kang, Wen Yang, Shuhua Yang, Cao Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Intervertebral Disc Degradation(IDD)
Sestrins; Autophagy
Endoplasmic reticulum (ER) stress
Online Access:https://www.karger.com/Article/FullText/487970

Internet

https://www.karger.com/Article/FullText/487970

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