Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines

Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines

Abstract Background Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D3 (1,25D; active vitamin D metabolite), are proposed to play a role in the atypical social behaviors associated with psychological conditions including autism spectrum d...

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Bibliographic Details
Main Authors: Marya S. Sabir, Mark R. Haussler, Sanchita Mallick, Ichiro Kaneko, Daniel A. Lucas, Carol A. Haussler, G. Kerr Whitfield, Peter W. Jurutka
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Genes & Nutrition
Subjects:
Autism spectrum disorders
Depression
Neuropsychiatric disorders
Social behavior
Tryptophan metabolism
Vitamin D receptor
Online Access:http://link.springer.com/article/10.1186/s12263-018-0605-7

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http://link.springer.com/article/10.1186/s12263-018-0605-7

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