Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin

Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin

Mitochondrial ferritin (FtMt) is an iron-transport protein with ferroxidase properties localized to mitochondria. Levels are generally low in all tissues, while increasing the expression of FtMt in neuronal-like cells has been shown to be protective. To determine whether FtMt has potential as a ther...

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Bibliographic Details
Main Authors: Anarmaa Mendsaikhan, Shigeko Takeuchi, Douglas G. Walker, Ikuo Tooyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuroprotection
free radical
mitochondria
iron
neurodegeneration
cell culture
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00470/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00470/full

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