Topaz-Denoise: general deep denoising models for cryoEM and cryoET

The low signal-to-noise ratio (SNR) in cryoEM images can make the first steps in cryoEM structure determination challenging, particularly for non-globular and small proteins. Here, the authors present Topaz-Denoise, a deep learning based method for micrograph denoising that significantly increases t...

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Bibliographic Details
Main Authors: Tristan Bepler, Kotaro Kelley, Alex J. Noble, Bonnie Berger
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18952-1