Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication

Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication

Innate immune responses mediated by IFN and inflammatory cytokines are critical for controlling virus replication. Nevertheless, exacerbated innate immune responses could be detrimental for the host and feedback mechanisms are needed to maintain the cellular homeostasis. In this work, we describe a...

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Bibliographic Details
Main Authors: Marta L. DeDiego, Aitor Nogales, Luis Martinez-Sobrido, David J. Topham
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
fkbp5
ifi44
ifn responses
antiviral responses
innate immunity
signaling transduction
virus-host interactions
Online Access:https://doi.org/10.1128/mBio.01839-19

Internet

https://doi.org/10.1128/mBio.01839-19

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