Higher binding affinity of furin for SARS-CoV-2 spike (S) protein D614G mutant could be associated with higher SARS-CoV-2 infectivity

Higher binding affinity of furin for SARS-CoV-2 spike (S) protein D614G mutant could be associated with higher SARS-CoV-2 infectivity

Objective: The coronavirus disease 2019 (COVID-19) pandemic has caused an exponential rise in death rates and hospitalizations. The aim of this study was to characterize the D614G substitution in the severe acute respiratory syndome coronavirus 2 (SARS-CoV-2) spike glycoprotein (S protein), which ma...

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Bibliographic Details
Main Authors: Anwar Mohammad, Eman Alshawaf, Sulaiman K. Marafie, Mohamed Abu-Farha, Jehad Abubaker, Fahd Al-Mulla
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:International Journal of Infectious Diseases
Subjects:
SARS-CoV-2
COVID-19
Furin
S protein
G clade
Interatomic binding
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971220322372

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http://www.sciencedirect.com/science/article/pii/S1201971220322372

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