Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review

Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review

ABSTRACT Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (statins) can disable the N-methyl-D-aspartate (NMDA) receptor through disruption of MLRs...

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Bibliographic Details
Main Authors: Júlia Niehues da Cruz, Débora Delwing Dal Magro, Daniela Delwing de Lima, José Geraldo Pereira da Cruz
Format: Article
Language:English
Published: Universidade de São Paulo 2017-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Anxiolytic effects
Membrane/lipid rafts
N-methyl-D-aspartate
Simvastatin.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100401&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100401&lng=en&tlng=en

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