Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction

Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction

Measurement of low-affinity protein–protein interactions is challenging; surface plasmon resonance requires high concentrations of reagents. Here the authors combine magneto-nanosensors with microfluidic chips and protein-conjugated magnetic nanoparticles to discover a low-affinity interaction betwe...

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Bibliographic Details
Main Authors: Jung-Rok Lee, Daniel J. B. Bechstein, Chin Chun Ooi, Ashka Patel, Richard S. Gaster, Elaine Ng, Lino C. Gonzalez, Shan X. Wang
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12220

Internet

https://doi.org/10.1038/ncomms12220

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