Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases

Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases

The Cia21 locus on chromosome 3 has been associated with rheumatoid arthritis severity in females. Here the authors show this locus houses a non-coding polymorphic estrogen receptor binding site and how it regulates neighbouring gene expression of CD2, implicating CD2 signalling in the sexual dimorp...

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Bibliographic Details
Main Authors: Gonzalo Fernandez Lahore, Michael Förster, Martina Johannesson, Pierre Sabatier, Erik Lönnblom, Mike Aoun, Yibo He, Kutty Selva Nandakumar, Roman A. Zubarev, Rikard Holmdahl
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25828-5

Internet

https://doi.org/10.1038/s41467-021-25828-5

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