Sustained release ivermectin-loaded solid lipid dispersion for subcutaneous delivery: in vitro and in vivo evaluation

Sustained release ivermectin-loaded solid lipid dispersion for subcutaneous delivery: in vitro and in vivo evaluation

This work aimed to develop a sustained release solid dispersion of ivermectin (IVM-SD) in a lipid matrix (hydrogenated castor oil, HCO) for subcutaneous delivery. Solvent-melting technology was employed to prepare IVM-SDs using HCO. The physicochemical properties of the IVM-SDs were evaluated by sca...

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Bibliographic Details
Main Authors: Mengmeng Lu, Dan Xiong, Weiwei Sun, Tong Yu, Zixia Hu, Jiafeng Ding, Yunpeng Cai, Shizhuang Yang, Baoliang Pan
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
ivermectin
sustained release
solid lipid dispersion
subcutaneous delivery
physicochemical properties
bioavailability
Online Access:http://dx.doi.org/10.1080/10717544.2017.1284945

Internet

http://dx.doi.org/10.1080/10717544.2017.1284945

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