Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor

Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor

Recently, the muscle-type nicotinic acetylcholine receptors (nAChRs) have been pursued as a potential target of several diseases, including myogenic disorders, muscle dystrophies and myasthenia gravis, etc. &#945;-conotoxin GI isolated from <i>Conus geographus</i> selectively and pot...

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Bibliographic Details
Main Authors: Jiong Ning, Rui Li, Jie Ren, Dongting Zhangsun, Xiaopeng Zhu, Yong Wu, Sulan Luo
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Marine Drugs
Subjects:
muscle-type nAChRs
α-conotoxin GI
structure-activity relationship
electrophysiological study
molecular dynamic simulations
Online Access:https://www.mdpi.com/1660-3397/16/12/507

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https://www.mdpi.com/1660-3397/16/12/507

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