Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor
Recently, the muscle-type nicotinic acetylcholine receptors (nAChRs) have been pursued as a potential target of several diseases, including myogenic disorders, muscle dystrophies and myasthenia gravis, etc. α-conotoxin GI isolated from <i>Conus geographus</i> selectively and pot...
Main Authors: | Jiong Ning, Rui Li, Jie Ren, Dongting Zhangsun, Xiaopeng Zhu, Yong Wu, Sulan Luo |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-12-01
|
Series: | Marine Drugs |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-3397/16/12/507 |
Similar Items
-
Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli
by: Xiaopeng Zhu, et al.
Published: (2016-01-01) -
α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice
by: Xiaodan Li, et al.
Published: (2020-12-01) -
Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA
by: Yong Wu, et al.
Published: (2014-01-01) -
Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB
by: Xincan Li, et al.
Published: (2020-03-01) -
DSPE-PEG Modification of α-Conotoxin TxID
by: Weinan Zhao, et al.
Published: (2019-06-01)