Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one such cell type, and defects in RNA splicing factors can lead to neurodegenerative diseases. Th...

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Bibliographic Details
Main Authors: Shelly Sorrells, Sara Nik, Mattie Casey, Rosannah C. Cameron, Harold Truong, Cristhian Toruno, Michelle Gulfo, Albert Lowe, Cicely Jette, Rodney A. Stewart, Teresa V. Bowman
Format: Article
Language:English
Published: The Company of Biologists 2018-02-01
Series:Disease Models & Mechanisms
Subjects:
Splicing
Radiation
Apoptosis
Zebrafish
R-loops
Neurons
Online Access:http://dmm.biologists.org/content/11/2/dmm031583

Internet

http://dmm.biologists.org/content/11/2/dmm031583

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