A strategy to protect off-the-shelf cell therapy products using virus-specific T-cells engineered to eliminate alloreactive T-cells

A strategy to protect off-the-shelf cell therapy products using virus-specific T-cells engineered to eliminate alloreactive T-cells

Abstract Background The use of “off-the-shelf” cellular therapy products derived from healthy donors addresses many of the challenges associated with customized cell products. However, the potential of allogeneic cell products to produce graft-versus-host disease (GVHD), and their likely rejection b...

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Bibliographic Details
Main Authors: David H. Quach, Luis Becerra-Dominguez, Rayne H. Rouce, Cliona M. Rooney
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Translational Medicine
Subjects:
Allogeneic T-cells
Alloreactive T-cells
Cellular therapy
Graft-vs-host disease
Immunotherapy
Off-the-shelf
Online Access:http://link.springer.com/article/10.1186/s12967-019-1988-y

Internet

http://link.springer.com/article/10.1186/s12967-019-1988-y

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