Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics

Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics

Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the physiological roles of the ER might be affected by such disrup...

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Bibliographic Details
Main Authors: Megan K. Oliva, Juan José Pérez-Moreno, Jillian O’Shaughnessy, Trevor J. Wardill, Cahir J. O’Kane
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neuroscience
Subjects:
hereditary spastic paraplegia
endoplasmic reticulum
calcium imaging
Drosophila
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00816/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00816/full

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