Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities

Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities

MYBPC3 mutations cause hypertrophic cardiomyopathy, which is frequently associated with mitral valve (MV) pathology. We reasoned that increased MV size is caused by localized growth factors with paracrine effects. We used high-resolution echocardiography to compare Mybpc3-null, heterozygous, and wil...

Full description

Bibliographic Details
Main Authors: Daniel P. Judge, Hany Neamatalla, Russell A. Norris, Robert A. Levine, Jonathan T. Butcher, Nicolas Vignier, Kevin H. Kang, Quangtung Nguyen, Patrick Bruneval, Marie-Cécile Perier, Emmanuel Messas, Xavier Jeunemaitre, Annemarieke de Vlaming, Roger Markwald, Lucie Carrier, Albert A. Hagège
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
mitral valve
TGFβ
hypertrophic cardiomyopathy
Online Access:http://www.mdpi.com/2308-3425/2/2/48

Internet

http://www.mdpi.com/2308-3425/2/2/48

Similar Items