Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities
MYBPC3 mutations cause hypertrophic cardiomyopathy, which is frequently associated with mitral valve (MV) pathology. We reasoned that increased MV size is caused by localized growth factors with paracrine effects. We used high-resolution echocardiography to compare Mybpc3-null, heterozygous, and wil...
Main Authors: | Daniel P. Judge, Hany Neamatalla, Russell A. Norris, Robert A. Levine, Jonathan T. Butcher, Nicolas Vignier, Kevin H. Kang, Quangtung Nguyen, Patrick Bruneval, Marie-Cécile Perier, Emmanuel Messas, Xavier Jeunemaitre, Annemarieke de Vlaming, Roger Markwald, Lucie Carrier, Albert A. Hagège |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-04-01
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Series: | Journal of Cardiovascular Development and Disease |
Subjects: | |
Online Access: | http://www.mdpi.com/2308-3425/2/2/48 |
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