Tumor necrosis factor receptor-associated factor 6 interaction with alpha-synuclein enhances cell death through the Nuclear Factor-kB pathway

Tumor necrosis factor receptor-associated factor 6 interaction with alpha-synuclein enhances cell death through the Nuclear Factor-kB pathway

Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by intracellular inclusions named Lewy bodies (LB), and alpha-synuclein (asyn) is the major component of these protein aggregates. The precise physiological and pathological roles of asyn are not fully understood....

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Bibliographic Details
Main Authors: Lidia M. Yshii, Adriana O. Manfiolli, Alexandre Denadai-Souza, Paula F. Kinoshita, Marcelo D. Gomes, Cristoforo Scavone
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:IBRO Reports
Subjects:
alpha-synuclein
cell death
cytokines
TRAF6 and NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2451830120300388

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http://www.sciencedirect.com/science/article/pii/S2451830120300388

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