The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection

The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection

Mycobacterium bovis (M. bovis) is the pathogen of animals and humans that can replicate in the phagosomes of myeloid cells. Cytosolic detection of bacterial products plays a crucial role in initiating the innate immune response, including autophagy activation and interferon-β (IFN-β) release. Althou...

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Bibliographic Details
Main Authors: Liu Chunfa, Sun Xin, Li Qiang, Srinand Sreevatsan, Lifeng Yang, Deming Zhao, Xiangmei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
IFI204
IFN-β
M. bovis
autophagy
DNA sensor
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00169/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00169/full

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