Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics

Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics

Poison inhibitors of DNA topoisomerase II (TOP2) are clinically used drugs that cause cancer cell death by inducing DNA damage, which mechanism of action is also associated with serious side effects such as secondary malignancy and cardiotoxicity. In contrast, TOP2 catalytic inhibitors induce limite...

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Bibliographic Details
Main Authors: Victor M. Matias-Barrios, Mariia Radaeva, Yi Song, Zaccary Alperstein, Ahn R. Lee, Veronika Schmitt, Joseph Lee, Fuqiang Ban, Ning Xie, Jianfei Qi, Nada Lallous, Martin E. Gleave, Artem Cherkasov, Xuesen Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
topoisomerase II
catalytic inhibitor
androgen receptor
prostate cancer
computer aided drug design
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.633142/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.633142/full

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