Liposome Consolidated with Cyclodextrin Provides Prolonged Drug Retention Resulting in Increased Drug Bioavailability in Brain

Liposome Consolidated with Cyclodextrin Provides Prolonged Drug Retention Resulting in Increased Drug Bioavailability in Brain

Although butylidenephthalide (BP) is an efficient anticancer drug, its poor bioavailability renders it ineffective for treating drug-resistant brain tumors. However, this problem is overcome through the use of noninvasive delivery systems, including intranasal administration. Herein, the bioavailabi...

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Bibliographic Details
Main Authors: En-Yi Lin, Yu-Shuan Chen, Yuan-Sheng Li, Syuan-Rong Chen, Chia-Hung Lee, Mao-Hsuan Huang, Hong-Meng Chuang, Horng-Jyh Harn, Hsueh-Hui Yang, Shinn-Zong Lin, Dar-Fu Tai, Tzyy-Wen Chiou
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma multiforme
butylidenephthalide
cyclodextrin
liposome
stability
bioavailability
Online Access:https://www.mdpi.com/1422-0067/21/12/4408

Internet

https://www.mdpi.com/1422-0067/21/12/4408

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