Cigarette Smoke Induces the Risk of Metabolic Bone Diseases: Transforming Growth Factor Beta Signaling Impairment via Dysfunctional Primary Cilia Affects Migration, Proliferation, and Differentiation of Human Mesenchymal Stem Cells

Cigarette Smoke Induces the Risk of Metabolic Bone Diseases: Transforming Growth Factor Beta Signaling Impairment via Dysfunctional Primary Cilia Affects Migration, Proliferation, and Differentiation of Human Mesenchymal Stem Cells

It is well established that smoking has detrimental effects on bone integrity and is a preventable risk factor for metabolic bone disorders. Following orthopedic surgeries, smokers frequently show delayed fracture healing associated with many complications, which results in prolonged hospital stays....

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Bibliographic Details
Main Authors: Romina H. Aspera-Werz, Tao Chen, Sabrina Ehnert, Sheng Zhu, Theresa Fröhlich, Andreas K. Nussler
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
cigarette smoke
TGF-β signaling
MSCs
smokers
fracture
primary cilia
bone metabolic diseases
osteoporosis
Smad signaling
Online Access:https://www.mdpi.com/1422-0067/20/12/2915

Internet

https://www.mdpi.com/1422-0067/20/12/2915

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