Imatinib Inhibits GH Secretion From Somatotropinomas

Imatinib Inhibits GH Secretion From Somatotropinomas

Background: Imatinib, a tyrosine kinase inhibitor, causes growth failure in children with chronic myeloid leukemia probably by targeting the growth hormone (GH)/insulin like growth factor-1 (IGF-1) axis. We aim to explore the imatinib targets expression in pituitary adenomas and study the effect of...

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Bibliographic Details
Main Authors: Prakamya Gupta, Ashutosh Rai, Kanchan Kumar Mukherjee, Naresh Sachdeva, Bishan Das Radotra, Raj Pal Singh Punia, Rakesh Kumar Vashista, Debasish Hota, Anand Srinivasan, Sivashanmugam Dhandapani, Sunil Kumar Gupta, Anil Bhansali, Pinaki Dutta
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Endocrinology
Subjects:
growth hormone
imatinib
somatotropinoma
c-kit
VEGF
PDGFR-α/β
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00453/full

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https://www.frontiersin.org/article/10.3389/fendo.2018.00453/full

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