Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes

Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes

Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus con...

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Bibliographic Details
Main Authors: Casey E. Romanoski, Xinshuai Qi, Shreya Sangam, Rebecca R. Vanderpool, Robert S. Stearman, Austin Conklin, Manuel Gonzalez-Garay, Franz Rischard, Ramon J. Ayon, Jian Wang, Tatum Simonson, Aleksandra Babicheva, Yinan Shi, Haiyang Tang, Ayako Makino, Yogendra Kanthi, Mark W. Geraci, Joe G.N. Garcia, Jason X.-J. Yuan, Ankit A. Desai
Format: Article
Language:English
Published: SAGE Publishing 2020-11-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045894020968531

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https://doi.org/10.1177/2045894020968531

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