Serum Free Immunoglobulins Light Chains: A Common Feature of Common Variable Immunodeficiency?

Serum Free Immunoglobulins Light Chains: A Common Feature of Common Variable Immunodeficiency?

Serum free light chain (sFLC) is a recently proposed biomarker for CVID diagnosis. Most CVID patients present low or undetectable sFLC up to 10-fold lower compared to other primary antibody deficiencies. Given that κ and λ light chains are normally secreted in excess with respect to immunoglobulins,...

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Bibliographic Details
Main Authors: Kissy Guevara-Hoyer, Juliana Ochoa-Grullón, Miguel Fernández-Arquero, Mariacruz Cárdenas, Rebeca Pérez de Diego, Silvia Sánchez-Ramón
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
common variable immunodeficiency
serum-free immunoglobulins light chains
diagnostic tool
prognostic biomarkers
primary immunodeficiencies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02004/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02004/full

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